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SASInstitute A00-282 Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Topic 1: Regulatory Submissions | 5% | - ICH and FDA guidelines - Compliance for clinical data reporting |
| Topic 2: Apply Statistical Procedures for Clinical Trials | 15% | - PROC MEANS, FREQ, TABULATE - Basic statistical analysis for clinical data |
| Topic 3: Clinical Trials Process | 5% | - Derive programming requirements from protocol and CRF - Clinical trial lifecycle and protocol |
| Topic 4: Transform or Summarize Clinical Trials Data | 15% | - Aggregation and transposition - Data step manipulation - Derive variables and study days |
| Topic 5: Report Clinical Trials Results | 10% | - Produce tables, listings, and figures - PROC REPORT and PROC PRINT |
| Topic 6: Macro Programming for Clinical Trials | 15% | - Create and call macros - Macro variables and parameters - Debugging macros |
| Topic 7: Validate Clinical Trial Data Reporting | 20% | - Validation principles - Use PROC COMPARE and log review - Programming validation techniques |
| Topic 8: Manage Clinical Trials Data | 5% | - Clean, merge, and subset data - Access and explore clinical datasets - Use SQL and dictionary tables |
| Topic 9: Clinical Trials Data Structures | 10% | - Define.xml and dataset specifications - CDISC standards: SDTM, ADaM - Clinical domain structures |
SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:
1. The PROC SGPLOT step below needs to be modified to format the values on the horizontal axis.
proc sgplot data = work.adlb;
histogram AVAL;
<insert code here>
run;
Which statement CANNOT be used to format the values due to a syntax error?
A) format AVAL 8.2;
B) format AVAL comma8.2;
C) xaxis valuesformat = 8.2;
D) xaxis valuesformat = comma8.2;
2. What is the definition for treatment-emergent adverse event (TEAE)?
A) AE that continued after the first dose of study drug
B) AE that started or worsened after the first dose of study drug
C) AE that improved after the first dose of study drug
D) AE that started 6 months after the last dose of study drug
3. You have been asked to import an Excel spreadsheet.
What will lead to substantial differences between the original Excel spreadsheet and the resulting SAS data set?
A) the number of rows to be read from the Excel file
B) multiple value types within a single row
C) the number of columns to be read from the Excel file
D) multiple value types within a single column
4. The print below shows the first four observations from the TEST2 dataset.
Variable names are given in the first row.
The statistical analysis plan (SAP) requests that a two sample t-test be performed to compare the mean of variable FINALBP for levels of the variable TRT.
You review the following code from a colleague:
proc ttest data=test2;
by trt;
var finalbp;
run;
This code does not produce the analysis requested by the SAP.
What is wrong with this code?
A) Variable FINALBP should be specified on a TWOSAMP statement instead of a VAR statement.
B) Variable TRT should be specified on a WEIGHT statement instead of a BY statement.
C) Variable FINALBP should be specified on a TEST statement instead of a VAR statement.
D) Variable TRT should be specified on a CLASS statement instead of a BY statement.
5. This question will ask you to provide a line of missing code.
Given the following demography (DM) data set sorted by site with character variables SUBJID, SITE, SEX, RACE and numeric variables ENROLLDAT and DOB:
The following SAS program is submitted:
%macro p_demog(bylist, varlist, statlist=);
proc sort data=derived.dm out=dm;
by &bylist;
proc means data=dm;
by &bylist;
var &varlist;
output out=stats &statlist;
run;
%mend p_demog;
Which call to the p_demog macro provides only the MEAN of AGE by SEX into the output dataset STATS?
A) %p_demog(statlist=%str(mean=mymeanvar), sex, varlist=age)
B) %p_demog(sex, age, statlist=%str(mean=mymeanvar))
C) %p_demog(statlist=%str(mean=mymeanvar), sex, age)
D) %p_demog(sex age statlist=%str(mean=mymeanvar))
Solutions:
| Question # 1 Answer: C | Question # 2 Answer: B | Question # 3 Answer: D | Question # 4 Answer: D | Question # 5 Answer: B |






